HitPredict

Interactor 1: CHM1B (Q7LBR1)
Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2)
Gene: CHMP1B

Interactor 2: SPAST (Q9UBP0)
Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)
Gene: SPAST

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	20719964
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0030496 - midbody GO:0031468 - nuclear membrane reassembly GO:0070062 - extracellular exosome and 1 others more... GO:0090148 - membrane fission
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 199 Hs			1 616
+	Hs
		208865 CHM2A_HUMAN (4-180): 3.37e-38: 132: 28.25		SPAST_HUMAN (1-616): 2.86e-168: 494: 100.00
+	Hs
		260145 CHM1B_HUMAN (1-199): 6.68e-41: 139: 100.00		VPS4B_HUMAN (289-613): 3.61e-112: 345: 38.97
+	Hs
		1185556 CHM1B_HUMAN (1-199): 6.68e-41: 139: 100.00		VPS4A_HUMAN (290-615): 5.95e-112: 343: 36.54
+	Dm
		1279493 Q95SH2_DROME (2-198): 4.98e-39: 134: 71.86		Q9Y162_DROME (321-613): 6.13e-113: 347: 38.67
+	Dm
		1373132 Q9VRJ5_DROME (5-197): 1.08e-38: 134: 15.39		Q9Y162_DROME (321-613): 6.13e-113: 347: 38.67
+	Hs
		208804 CHM2A_HUMAN (4-180): 3.37e-38: 132: 28.25		VPS4B_HUMAN (289-613): 3.61e-112: 345: 38.97
+	Sc
		732854 DID4_YEAST (4-198): 6.07e-38: 132: 21.50		VPS4_YEAST (290-613): 1.84e-112: 345: 36.84
+	Hs
		208869 CHM2A_HUMAN (4-180): 3.37e-38: 132: 28.25		VPS4A_HUMAN (290-615): 5.95e-112: 343: 36.54
+	Hs
		260164 CHM2B_HUMAN (4-195): 2.49e-37: 130: 18.78		VPS4B_HUMAN (289-613): 3.61e-112: 345: 38.97
+	Hs
		1357379 CHMP3_HUMAN (4-183): 9.18e-38: 131: 16.11		VPS4A_HUMAN (290-615): 5.95e-112: 343: 36.54
+	Dm
		1362012 Q9VBI3_DROME (4-190): 7.68e-36: 127: 26.74		Q9Y162_DROME (321-613): 6.13e-113: 347: 38.67
+	Dm
		1371193 Q9VN02_DROME (4-199): 5.83e-36: 127: 12.81		Q9Y162_DROME (321-613): 6.13e-113: 347: 38.67
+	Hs
		1357378 CHM2B_HUMAN (4-195): 2.49e-37: 130: 18.78		VPS4A_HUMAN (290-615): 5.95e-112: 343: 36.54
+	Hs
		260156 CHM1A_HUMAN (4-197): 2.33e-36: 127: 55.10		VPS4B_HUMAN (289-613): 3.61e-112: 345: 38.97
+	Hs
		1336687 CHM1A_HUMAN (4-197): 2.33e-36: 127: 55.10		VPS4A_HUMAN (290-615): 5.95e-112: 343: 36.54
+	Dm
		1248702 Q8SXB1_DROME (4-190): 2.16e-33: 120: 26.74		Q9Y162_DROME (321-613): 6.13e-113: 347: 38.67
+	Sc
		857404 DID2_YEAST (2-196): 2.49e-30: 112: 41.41		VPS4_YEAST (290-613): 1.84e-112: 345: 36.84
+	Sc
		732543 VPS24_YEAST (11-189): 2.09e-29: 110: 16.11		VPS4_YEAST (290-613): 1.84e-112: 345: 36.84
+	Hs
		260159 CHMP5_HUMAN (15-186): 4.8e-26: 101: 15.82		VPS4B_HUMAN (289-613): 3.61e-112: 345: 38.97
+	Mm
		804060 CHM2A_MOUSE (4-183): 5.36e-38: 132: 28.33		VPS4B_MOUSE (324-581): 1.19e-68: 231: 48.65