HitPredict

Interactor 1: RIR2B (Q7LG56)
Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
Gene: RRM2B

Interactor 2: RIR2B (Q7LG56)
Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
Gene: RRM2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.839

The method score is based on:

Property Details
Experiments 25416956, 25502805, 31515488
Identification Methods two hybrid, two hybrid array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ribonuc_red_sm~Ribonuc_red_sm
Common GO terms GO:0000731 - DNA synthesis involved in DNA repair
GO:0001822 - kidney development
GO:0003014 - renal system process
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005654 - nucleoplasm
and 15 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 351
Hs

1 351
+ Hs
+ Hs
+ Vv
+ Sc
+ Ce
+ Sc
+ Sc
+ Hh
+ Hh
+ Hh
+ Ha
+ Ec
+ Ec
+ Mp
+ Mt

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024