HitPredict - High confidence protein-protein interactions

Interactor 1: TNF18 (Q7TS55)
Tumor necrosis factor ligand superfamily member 18 (GITR ligand) (GITRL) (Glucocorticoid-induced TNF-related ligand)
Gene: Tnfsf18

Interactor 2: TNF18 (Q7TS55)
Tumor necrosis factor ligand superfamily member 18 (GITR ligand) (GITRL) (Glucocorticoid-induced TNF-related ligand)
Gene: Tnfsf18

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.812

Property	Details
Experiments	18178614, 18182486
Identification Methods	x-ray crystallography, cosedimentation in solution, molecular sieving
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	TNF~TNF
Common GO terms	GO:0002250 - adaptive immune response GO:0002309 - T cell proliferation involved in immune response GO:0005125 - cytokine activity GO:0005164 - tumor necrosis factor receptor binding GO:0005615 - extracellular space and 13 others more... GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0010759 - positive regulation of macrophage chemotaxis GO:0032813 - tumor necrosis factor receptor superfamily binding GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0042129 - regulation of T cell proliferation GO:0043254 - regulation of protein-containing complex assembly GO:0045785 - positive regulation of cell adhesion GO:0050729 - positive regulation of inflammatory response GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0090026 - positive regulation of monocyte chemotaxis GO:2000329 - negative regulation of T-helper 17 cell lineage commitment GO:2000508 - regulation of dendritic cell chemotaxis
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	173
Mm

1	173

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024