HitPredict

Interactor 1: AIP (O00170)
AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9)
Gene: AIP

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.80	0.764

Property	Details
Experiments	19366855, 32062451, 35384245
Identification Methods	affinity chromatography technology, protein complementation assay, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 1114
+	Rn
		102577 AIP_RAT (1-330): 1.1e-85: 262: 94.24		RET_RAT (1-1114): 0: 1316: 85.29
+	Hs
		434258 SGTB_HUMAN (111-315): 2.91e-40: 145: 15.94		RET_HUMAN (1-1114): 0: 1295: 100.00
+	Hs
		118691 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16
+	Hs
		118663 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		118667 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		118668 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		118739 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74
+	Hs
		118690 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		384721 PPID_HUMAN (16-329): 5.75e-64: 208: 17.21		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		338379 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		383783 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		338303 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		338429 FKBP8_HUMAN (6-330): 4.65e-55: 186: 17.23		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		383803 FKBP8_HUMAN (6-330): 4.65e-55: 186: 17.23		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		384787 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		384676 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		384834 FKBP8_HUMAN (6-330): 4.65e-55: 186: 17.23		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Hs
		169174 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		MUSK_HUMAN (396-1018): 1.21e-135: 434: 25.28
+	Hs
		118700 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25