HitPredict

Interactor 1: AIP (O00170)
AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9)
Gene: AIP

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	25036637, 21170051, 28634279, 19375531
Identification Methods	affinity chromatography technology, surface plasmon resonance, cosedimentation in solution, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	FKBP_C~HSP90
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0034751 - aryl hydrocarbon receptor complex and 1 others more... GO:0051082 - unfolded protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 724
+	Hs
		432312 AIPL1_HUMAN (3-330): 2.03e-95: 289: 49.39		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		111929 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		118674 AIP_HUMAN (1-330): 2.25e-86: 264: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438106 PPID_HUMAN (16-329): 5.75e-64: 208: 17.21		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431781 PPID_HUMAN (16-329): 5.75e-64: 208: 17.21		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438136 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438089 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438169 FKBP8_HUMAN (6-330): 4.65e-55: 186: 17.23		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		111937 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431818 FKBP5_HUMAN (5-330): 6.89e-57: 192: 15.20		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		111936 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431755 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431850 FKBP8_HUMAN (6-330): 4.65e-55: 186: 17.23		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Mm
		432409 FKBP4_MOUSE (9-330): 1.66e-55: 188: 19.20		HS90A_MOUSE (1-724): 0: 1068: 84.31
+	At
		878280 CYP40_ARATH (13-328): 3.69e-63: 206: 19.59		HS902_ARATH (10-724): 0: 1003: 66.85
+	At
		646590 CYP40_ARATH (13-328): 3.69e-63: 206: 19.59		HS901_ARATH (10-724): 0: 999: 67.97
+	Ce
		220015 O45418_CAEEL (10-330): 1.81e-55: 188: 17.42		HSP90_CAEEL (8-724): 0: 976: 74.34
+	Hs
		972520 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		1053004 FKBP8_HUMAN (6-330): 4.65e-55: 186: 17.23		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		972530 FKBP4_HUMAN (9-330): 4.49e-55: 187: 18.89		Q6PK50_HUMAN (1-350): 0: 618: 99.71