HitPredict

Interactor 1: RAX2 (Q7YRX0)
Retina and anterior neural fold homeobox protein 2 (Q50-type retinal homeobox protein) (Retina and anterior neural fold homeobox-like protein 1)
Gene: RAX2

Interactor 2: CRX (Q9XSK0)
Cone-rod homeobox protein
Gene: CRX

Species: Bos taurus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15028672
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0007601 - visual perception and 1 others more... GO:0050896 - response to stimulus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 184 Bt			1 299
+	Hs
		197795 RAX2_HUMAN (1-184): 4.21e-43: 143: 91.30		CRX_HUMAN (1-299): 3.73e-56: 185: 97.66
+	Mm
		222324 Q8VD35_MOUSE (9-158): 8.95e-36: 127: 32.40		CRX_MOUSE (1-299): 5.35e-54: 179: 95.65
+	Mm
		1257445 Q8VD35_MOUSE (9-158): 8.95e-36: 127: 32.40		DMBX1_MOUSE (6-194): 1.7e-45: 159: 33.82
+	Mm
		945791 OTX2_MOUSE (9-158): 8.57e-36: 127: 32.40		DMBX1_MOUSE (6-194): 1.7e-45: 159: 33.82
+	Mm
		192281 ALX4_MOUSE (19-177): 1.85e-35: 129: 36.20		PAX3_MOUSE (13-296): 2.13e-43: 156: 24.57
+	Hs
		686545 OTX2_HUMAN (9-158): 7.31e-36: 128: 32.40		OTX2_HUMAN (1-299): 4.97e-42: 148: 47.90
+	Mm
		192304 ALX4_MOUSE (19-177): 1.85e-35: 129: 36.20		Q8VD35_MOUSE (1-299): 2.53e-41: 146: 48.22
+	Mm
		945790 OTX2_MOUSE (9-158): 8.57e-36: 127: 32.40		OTX2_MOUSE (1-299): 1.21e-41: 147: 47.90
+	Mm
		192291 ALX4_MOUSE (19-177): 1.85e-35: 129: 36.20		PRRX1_MOUSE (44-182): 4.34e-40: 141: 35.97
+	Mm
		192303 ALX4_MOUSE (19-177): 1.85e-35: 129: 36.20		Q8R0B5_MOUSE (1-299): 2.57e-38: 138: 44.30
+	Hs
		304490 PRRX1_HUMAN (3-173): 6.6e-36: 127: 39.23		ALX3_HUMAN (6-224): 4.94e-37: 136: 31.08
+	Mm
		192276 RX_MOUSE (10-181): 2.02e-36: 130: 45.25		ALX4_MOUSE (3-192): 1.41e-33: 128: 26.32
+	Hs
		1077278 ALX1_HUMAN (1-173): 3.4e-37: 132: 30.51		ALX4_HUMAN (3-192): 2.07e-32: 125: 26.32
+	Mm
		192275 ALX4_MOUSE (19-177): 1.85e-35: 129: 36.20		ALX4_MOUSE (3-192): 1.41e-33: 128: 26.32
+	Hs
		686548 OTX2_HUMAN (9-158): 7.31e-36: 128: 32.40		LHX1_HUMAN (2-252): 1.05e-33: 128: 22.13
+	Hs
		1328470 ALX4_HUMAN (8-184): 7.61e-36: 130: 33.70		ALX4_HUMAN (3-192): 2.07e-32: 125: 26.32
+	Mm
		192277 ALX4_MOUSE (19-177): 1.85e-35: 129: 36.20		LMX1B_MOUSE (1-216): 2.03e-32: 125: 18.92