HitPredict

Interactor 1: ZN550 (Q7Z398)
Zinc finger protein 550
Gene: ZNF550

Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0046872 - metal ion binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 422 Hs			1 747
+	Hs
		1282571 ZN566_HUMAN (7-418): 4.67e-164: 469: 41.55		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		1055967 ZN460_HUMAN (195-402): 2.94e-70: 233: 55.29		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		1289412 ZNF2_HUMAN (54-308): 4.09e-60: 203: 30.98		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		1205169 Z354C_HUMAN (196-400): 1.25e-57: 199: 49.27		SIR1_HUMAN (1-747): 0: 1052: 100.00