HitPredict

Interactor 1: PARPT (Q7Z3E1)
Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)
Gene: TIPARP

Interactor 2: SETD2 (Q9BYW2)
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)
Gene: SETD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35439318
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0046872 - metal ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 657 Hs			1 2564
+	Hs
		1188822 PARPT_HUMAN (1-657): 0: 1089: 100.00		NSD3_HUMAN (1410-1728): 2.45e-77: 287: 31.33
+	Hs
		331836 PARPT_HUMAN (1-657): 0: 1089: 100.00		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		1188726 PARPT_HUMAN (1-657): 0: 1089: 100.00		NSD1_HUMAN (1458-1727): 5.38e-73: 275: 32.73
+	Hs
		1188881 PARPT_HUMAN (1-657): 0: 1089: 100.00		EHMT1_HUMAN (1432-1726): 8.57e-72: 268: 24.38
+	Hs
		1188725 PARPT_HUMAN (1-657): 0: 1089: 100.00		EHMT2_HUMAN (1443-1686): 2.36e-66: 250: 25.28
+	Hs
		331835 ZCCHV_HUMAN (202-650): 1.19e-147: 452: 26.47		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		1080071 ZCCHV_HUMAN (202-650): 1.19e-147: 452: 26.47		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36