HitPredict

Interactor 1: NT2NA (Q7Z3S9)
Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)
Gene: NOTCH2NLA

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 236 Hs			1 1731
+	Hs
		804330 NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316313 JAG2_HUMAN (8-209): 1.76e-16: 80.1: 31.86		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		980523 NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1167035 FAT4_HUMAN (5-97): 1.2e-11: 65.8: 23.53		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316311 NOTC3_HUMAN (12-198): 1.58e-11: 65.5: 29.67		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Dm
		246781 TENM_DROME (2-124): 1.24e-14: 74.7: 17.71		Q0KIE7_DROME (30-505): 2.28e-87: 318: 16.35
+	Hs
		166914 NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		167042 NOTC3_HUMAN (12-198): 1.58e-11: 65.5: 29.67		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		1167037 FAT4_HUMAN (5-97): 1.2e-11: 65.8: 23.53		TNKS2_HUMAN (220-558): 1.49e-36: 153: 12.29
+	Dm
		65546 NOTCH_DROME (10-236): 6.06e-15: 75.8: 21.99		A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17
+	Hs
		946786 CRUM1_HUMAN (8-143): 8.13e-24: 101: 28.31		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Hs
		804293 NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Mm
		1142610 DLL1_MOUSE (9-236): 1.7e-22: 97.4: 27.16		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Hs
		980449 NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		132263 DLL1_HUMAN (43-236): 1.42e-21: 94.7: 25.56		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Dm
		706662 FAT_DROME (145-236): 1.12e-20: 92.4: 24.17		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Hs
		1237561 NOTC3_HUMAN (12-198): 1.58e-11: 65.5: 29.67		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Mm
		1193399 JAG2_MOUSE (12-197): 7.19e-15: 75.5: 30.66		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Dm
		485032 DL_DROME (12-201): 4.43e-17: 81.6: 33.33		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Dm
		422915 NOTCH_DROME (10-236): 6.06e-15: 75.8: 21.99		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31