HitPredict

Interactor 1: TT21B (Q7Z4L5)
Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog)
Gene: TTC21B

Interactor 2: WDR35 (Q9P2L0)
WD repeat-containing protein 35 (Intraflagellar transport protein 121 homolog)
Gene: WDR35

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.618

Property	Details
Experiments	27173435, 27932497
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005929 - cilium GO:0030991 - intraciliary transport particle A GO:0035721 - intraciliary retrograde transport GO:0060271 - cilium assembly GO:0061512 - protein localization to cilium and 1 others more... GO:0097542 - ciliary tip
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1316 Hs			1 1181
+	Hs
		1190475 TT21B_HUMAN (1-1316): 0: 846: 100.00		IF122_HUMAN (1-1148): 1.25e-171: 542: 14.79
+	Hs
		1190468 TT21B_HUMAN (1-1316): 0: 846: 100.00		WDR19_HUMAN (18-1180): 8.4e-57: 217: 11.51
+	Hs
		1242712 TT21A_HUMAN (2-1316): 0: 848: 51.10		IF140_HUMAN (689-1078): 4.66e-20: 99.1: 15.39
+	Hs
		1190473 TT21B_HUMAN (1-1316): 0: 846: 100.00		IF140_HUMAN (689-1078): 4.66e-20: 99.1: 15.39
+	Ce
		953726 TTC21_CAEEL (8-1315): 0: 607: 29.93		P90757_CAEEL (710-1087): 8.69e-13: 75.2: 16.09
+	Hs
		684451 STIP1_HUMAN (95-435): 5.85e-09: 62.3: 14.45		COPB2_HUMAN (1-861): 1.36e-106: 358: 12.85
+	Hs
		300167 PRP6_HUMAN (827-1315): 4.26e-23: 108: 11.87		SMU1_HUMAN (5-328): 4.34e-61: 220: 15.24
+	Hs
		684773 STIP1_HUMAN (95-435): 5.85e-09: 62.3: 14.45		SMU1_HUMAN (5-328): 4.34e-61: 220: 15.24
+	Hs
		174768 OGT1_HUMAN (11-423): 9.34e-28: 123: 11.91		WDR5_HUMAN (12-283): 1.99e-38: 148: 14.64
+	Hs
		300095 PRP6_HUMAN (827-1315): 4.26e-23: 108: 11.87		WDR5_HUMAN (12-283): 1.99e-38: 148: 14.64
+	Hs
		175177 OGT1_HUMAN (11-423): 9.34e-28: 123: 11.91		TBL1R_HUMAN (5-186): 1.68e-28: 123: 13.54
+	Mm
		1142546 IFT88_MOUSE (864-1314): 9.01e-29: 127: 11.63		IFT80_MOUSE (2-229): 1.3e-18: 93.9: 18.07
+	Hs
		1024279 IFT88_HUMAN (864-1316): 3.63e-25: 115: 12.55		IF172_HUMAN (710-1118): 1.23e-20: 101: 12.79
+	Hs
		1024278 IFT88_HUMAN (864-1316): 3.63e-25: 115: 12.55		IFT80_HUMAN (2-229): 1.08e-18: 94.2: 17.65
+	Hs
		684552 STIP1_HUMAN (95-435): 5.85e-09: 62.3: 14.45		COPA_HUMAN (7-402): 5.93e-21: 101: 12.32
+	Hs
		685083 STIP1_HUMAN (95-435): 5.85e-09: 62.3: 14.45		IF172_HUMAN (710-1118): 1.23e-20: 101: 12.79