HitPredict

Interactor 1: BRAP (Q7Z569)
BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63)
Gene: BRAP

Interactor 2: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	18796711, 18332145, 14724641
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007265 - Ras protein signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 923
+	Mm
		1142166 BRAP_MOUSE (1-592): 0: 707: 90.88		KSR1_MOUSE (1-923): 0: 715: 84.42
+	Hs
		542894 BRAP_HUMAN (1-592): 0: 706: 100.00		BRAF_HUMAN (252-914): 2.03e-148: 459: 22.80
+	Hs
		374452 BRAP_HUMAN (1-592): 0: 706: 100.00		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Mm
		1307871 BRAP_MOUSE (1-592): 0: 707: 90.88		RAF1_MOUSE (232-908): 1.01e-140: 435: 22.40
+	Hs
		1072556 UBP32_HUMAN (349-586): 4.39e-40: 159: 13.55		EPHA7_HUMAN (215-914): 9.83e-149: 467: 14.59
+	Hs
		665351 HDAC6_HUMAN (301-392): 2.71e-31: 131: 24.49		EPHA2_HUMAN (223-917): 2.52e-144: 454: 14.62