HitPredict

Interactor 1: I2BP2 (Q7Z5L9)
Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)
Gene: IRF2BP2

Interactor 2: I2BP1 (Q8IU81)
Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1)
Gene: IRF2BP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	28514442, 21444724, 33961781, 26593974
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 587 Hs			1 584
+	Hs
		1215898 I2BP1_HUMAN (5-586): 1.02e-134: 407: 32.58		I2BP1_HUMAN (1-584): 0: 879: 100.00
+	Hs
		1191122 I2BP2_HUMAN (1-587): 0: 697: 100.00		I2BP2_HUMAN (7-263): 1.14e-62: 218: 29.94
+	Hs
		1191146 I2BP2_HUMAN (1-587): 0: 697: 100.00		I2BPL_HUMAN (2-84): 3.89e-28: 121: 65.48
+	Hs
		1215913 I2BP1_HUMAN (5-586): 1.02e-134: 407: 32.58		I2BPL_HUMAN (2-84): 3.89e-28: 121: 65.48
+	Hs
		1328578 I2BPL_HUMAN (4-346): 2.57e-88: 292: 38.48		I2BPL_HUMAN (2-84): 3.89e-28: 121: 65.48
+	Ce
		70254 B2D6P5_CAEEL (1-99): 1.34e-27: 117: 50.51		B2D6P5_CAEEL (9-100): 1.35e-34: 137: 40.78
+	Ce
		954965 P92004_CAEEL (13-99): 1.93e-27: 117: 55.17		P92004_CAEEL (9-100): 1.53e-34: 137: 40.78