HitPredict

Interactor 1: SPRE1 (Q7Z699)
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
Gene: SPRED1

Interactor 2: CIB1 (Q99828)
Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28)
Gene: CIB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0030291 - protein serine/threonine kinase inhibitor activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 444 Hs			1 191
+	Hs
		1191592 SPRE1_HUMAN (1-444): 3.81e-177: 504: 100.00		KCIP2_HUMAN (9-190): 1.3e-48: 160: 21.08
+	Hs
		1191628 SPRE1_HUMAN (1-444): 3.81e-177: 504: 100.00		HPCL4_HUMAN (1-184): 1.24e-49: 160: 23.81
+	Hs
		917031 SPRE1_HUMAN (1-444): 3.81e-177: 504: 100.00		VISL1_HUMAN (1-184): 1.14e-48: 158: 21.69
+	Hs
		740670 SPRE1_HUMAN (1-444): 3.81e-177: 504: 100.00		HPCL1_HUMAN (1-188): 7.49e-44: 146: 21.99
+	Hs
		901310 SPRE1_HUMAN (1-444): 3.81e-177: 504: 100.00		NCALD_HUMAN (1-188): 6.85e-43: 143: 20.94
+	Hs
		906770 SPRE2_HUMAN (1-444): 1.36e-148: 430: 50.44		NCS1_HUMAN (1-190): 1.27e-52: 168: 23.83
+	Hs
		917030 SPRE2_HUMAN (1-444): 1.36e-148: 430: 50.44		VISL1_HUMAN (1-184): 1.14e-48: 158: 21.69
+	Hs
		208415 SPY3_HUMAN (201-435): 5.31e-43: 154: 16.79		VISL1_HUMAN (1-184): 1.14e-48: 158: 21.69