HitPredict

Interactor 1: ANS1B (Q7Z6G8)
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)
Gene: ANKS1B

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	unassigned1973
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, Ank_2~SH3_9
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1248 Hs			1 639
+	Hs
		209098 ANS1B_HUMAN (1-1248): 0: 869: 100.00		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Mm
		1206665 ANS1B_MOUSE (1-1241): 0: 837: 93.00		SRGP2_MOUSE (2-443): 2.8e-44: 172: 11.52
+	Mm
		1206687 ANS1B_MOUSE (1-1241): 0: 837: 93.00		ARHG7_MOUSE (230-378): 9.82e-13: 73.4: 26.17
+	Mm
		1206702 ANS1B_MOUSE (1-1241): 0: 837: 93.00		ITSN1_MOUSE (1-55): 4.64e-10: 65.3: 41.82
+	Hs
		1115812 Q49AR9_HUMAN (790-1232): 5.08e-100: 332: 57.88		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1268522 ANS1A_HUMAN (25-838): 8.72e-45: 179: 15.31		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1268487 ANS1A_HUMAN (25-838): 8.72e-45: 179: 15.31		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		235513 Q49AR9_HUMAN (790-1232): 5.08e-100: 332: 57.88		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28
+	Dm
		1360790 TNKS_DROME (2-733): 4.18e-51: 199: 13.82		Q9VA36_DROME (4-395): 1.02e-46: 179: 26.40
+	Hs
		1263386 CSKI2_HUMAN (648-940): 2.33e-13: 77.1: 21.33		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		253412 TANC2_HUMAN (104-807): 1.54e-29: 130: 11.73		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		209131 CSKI2_HUMAN (648-940): 2.33e-13: 77.1: 21.33		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		235561 ANS1A_HUMAN (25-838): 8.72e-45: 179: 15.31		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28
+	Hs
		1256280 TANC2_HUMAN (104-807): 1.54e-29: 130: 11.73		SH3R3_HUMAN (5-625): 1.58e-17: 88.8: 13.36
+	Hs
		1078859 MIB1_HUMAN (2-184): 1.72e-32: 139: 21.18		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Ce
		1274646 Q93203_CAEEL (6-881): 1.23e-25: 117: 11.52		Q9U2T9_CAEEL (27-492): 3.56e-11: 68.5: 13.89
+	Hs
		557753 CSKI2_HUMAN (648-940): 2.33e-13: 77.1: 21.33		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		557660 ANK2_HUMAN (66-258): 2.91e-10: 67.4: 30.05		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		257713 ANR17_HUMAN (2-85): 8.33e-14: 79.1: 26.04		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		64307 AN36A_HUMAN (3-114): 8.02e-11: 68.9: 22.76		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64