HitPredict

Interactor 1: SH3R1 (Q7Z6J0)
E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)
Gene: SH3RF1

Interactor 2: SH3R2 (Q8TEC5)
E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2)
Gene: SH3RF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 22128169
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SH3_1~SH3_1, SH3_1~SH3_2, SH3_2~SH3_9, SH3_9~SH3_9
Common GO terms GO:0016567 - protein ubiquitination
GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066 - negative regulation of apoptotic process
GO:0046330 - positive regulation of JNK cascade
GO:0046872 - metal ion binding
and 2 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 888
Hs

1 729
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Last updated: 15 Jul 2024