HitPredict

Interactor 1: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Interactor 2: USP9X (Q93008)
Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)
Gene: USP9X

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	20023629, 21907705
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 4374 Hs			1 2554
+	Hs
		1273700 ITCH_HUMAN (3507-4372): 0: 672: 23.10		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		125624 WWP2_HUMAN (3506-4372): 0: 624: 24.57		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1273741 SMUF1_HUMAN (3772-4371): 0: 620: 32.84		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1273724 WWP1_HUMAN (3507-4372): 0: 613: 22.55		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1273751 HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1192154 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Mm
		1149452 HUWE1_MOUSE (1-4374): 0: 3203: 96.37		UBP7_MOUSE (1469-2119): 1.12e-95: 339: 18.82
+	Hs
		125794 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UBP24_HUMAN (36-2478): 0: 2211: 29.78
+	Hs
		64219 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UBP27_HUMAN (1524-1949): 2.29e-96: 321: 17.61
+	Hs
		259303 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UBP12_HUMAN (1519-1957): 8.45e-94: 311: 21.51
+	Hs
		125625 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Hs
		1273807 NED4L_HUMAN (3542-4372): 0: 618: 27.53		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Hs
		1176343 HECW1_HUMAN (3082-4373): 1.49e-161: 549: 18.31		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82