HitPredict

Interactor 1: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Interactor 2: FAF2 (Q96CS3)
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Gene: FAF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25147182, 18775313
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 4374 Hs			1 445
+	Hs
		979321 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		UBXN1_HUMAN (295-439): 7.93e-19: 88.4: 16.36
+	Hs
		1287185 SMUF1_HUMAN (3772-4371): 0: 620: 32.84		FAF2_HUMAN (1-445): 1.33e-143: 419: 100.00
+	Hs
		299472 SMUF1_HUMAN (3772-4371): 0: 620: 32.84		UBXN7_HUMAN (1-441): 1.1e-116: 352: 16.34
+	Hs
		125790 WWP2_HUMAN (3506-4372): 0: 624: 24.57		FAF1_HUMAN (112-440): 5.62e-83: 269: 24.79
+	Sc
		765386 RSP5_YEAST (3659-4372): 0: 595: 27.62		UBX2_YEAST (9-430): 9.04e-66: 222: 16.38
+	Sc
		765431 RSP5_YEAST (3659-4372): 0: 595: 27.62		UBX3_YEAST (121-444): 1.7e-59: 203: 22.81