HitPredict

Interactor 1: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Interactor 2: UN45A (Q9H3U1)
Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)
Gene: UNC45A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25147182
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030154 - cell differentiation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 4374 Hs			1 944
+	Hs
		858646 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Mm
		103656 HUWE1_MOUSE (1-4374): 0: 3203: 96.37		G5E8T2_MOUSE (7-436): 2.67e-44: 176: 13.17
+	Mm
		291320 HUWE1_MOUSE (1-4374): 0: 3203: 96.37		TTC3_MOUSE (7-436): 3.44e-44: 176: 13.17
+	Hs
		175005 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		684846 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Mm
		1186484 HUWE1_MOUSE (1-4374): 0: 3203: 96.37		OGT1_MOUSE (3-192): 2.11e-24: 112: 12.63
+	Hs
		1294863 ITCH_HUMAN (3507-4372): 0: 672: 23.10		RPAP3_HUMAN (15-343): 5.32e-41: 163: 17.06
+	Hs
		125715 WWP2_HUMAN (3506-4372): 0: 624: 24.57		RPAP3_HUMAN (15-343): 5.32e-41: 163: 17.06
+	Hs
		865086 SMUF2_HUMAN (3771-4371): 0: 611: 33.44		TTC3_HUMAN (7-436): 6.41e-44: 175: 13.17
+	Ce
		1094404 WWP1_CAEEL (3848-4372): 0: 610: 30.84		Q21746_CAEEL (11-234): 2.39e-38: 148: 19.64
+	Hs
		808274 NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46		RPAP3_HUMAN (15-343): 5.32e-41: 163: 17.06
+	Hs
		125007 WWP2_HUMAN (3506-4372): 0: 624: 24.57		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		175222 SMUF1_HUMAN (3772-4371): 0: 620: 32.84		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Dm
		1366964 Q9W325_DROME (3947-4373): 8.19e-180: 562: 35.58		Q9VH81_DROME (6-180): 1.39e-38: 153: 22.29
+	Hs
		684966 NED4L_HUMAN (3542-4372): 0: 618: 27.53		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Hs
		1078503 HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49		TOM34_HUMAN (2-139): 4.73e-31: 126: 27.54
+	Ce
		185196 Q9GUP2_CAEEL (3471-4374): 1.65e-163: 575: 41.47		OGT1_CAEEL (64-469): 3.04e-16: 86: 10.31
+	Hs
		1350493 HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49		Z3H7B_HUMAN (21-143): 1.06e-11: 71.2: 33.33