HitPredict

Interactor 1: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Interactor 2: UBE2T (Q9NPD8)
Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)
Gene: UBE2T

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33542213
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con, UBA~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006513 - protein monoubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4374 Hs			1 197
+	Hs
		849353 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		UB2D1_HUMAN (2-152): 1.05e-76: 228: 41.72
+	Hs
		919765 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		UB2D2_HUMAN (2-152): 1.52e-76: 227: 41.72
+	Hs
		895829 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		UB2D3_HUMAN (2-152): 2.48e-75: 224: 41.06
+	Hs
		1192156 HUWE1_HUMAN (1-4374): 0: 3240: 100.00		UB2E3_HUMAN (3-152): 1.45e-68: 209: 40.00
+	Hs
		1294888 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UB2D4_HUMAN (2-152): 1.11e-77: 230: 39.74
+	Hs
		849411 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UB2D1_HUMAN (2-152): 1.05e-76: 228: 41.72
+	Hs
		919827 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UB2D2_HUMAN (2-152): 1.52e-76: 227: 41.72
+	Hs
		895882 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UB2D3_HUMAN (2-152): 2.48e-75: 224: 41.06
+	Hs
		1294835 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UB2E2_HUMAN (3-152): 6.78e-69: 210: 40.00
+	Hs
		1282329 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UB2E3_HUMAN (3-152): 1.45e-68: 209: 40.00
+	Hs
		851871 ITCH_HUMAN (3507-4372): 0: 672: 23.10		UB2E1_HUMAN (3-152): 1.27e-67: 206: 40.00
+	Hs
		125808 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UB2D4_HUMAN (2-152): 1.11e-77: 230: 39.74
+	Hs
		125262 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UB2D1_HUMAN (2-152): 1.05e-76: 228: 41.72
+	Hs
		125335 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UB2D2_HUMAN (2-152): 1.52e-76: 227: 41.72
+	Hs
		125300 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UB2D3_HUMAN (2-152): 2.48e-75: 224: 41.06
+	Hs
		849452 SMUF1_HUMAN (3772-4371): 0: 620: 32.84		UB2D1_HUMAN (2-152): 1.05e-76: 228: 41.72
+	Dm
		854579 SUDX_DROME (3526-4371): 0: 636: 23.22		UBCD2_DROME (3-152): 1.83e-69: 212: 38.67
+	Hs
		125655 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UB2E2_HUMAN (3-152): 6.78e-69: 210: 40.00
+	Hs
		125629 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UB2E3_HUMAN (3-152): 1.45e-68: 209: 40.00
+	Hs
		125263 WWP2_HUMAN (3506-4372): 0: 624: 24.57		UB2E1_HUMAN (3-152): 1.27e-67: 206: 40.00