HitPredict

Interactor 1: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Interactor 2: RNF11 (Q9Y3C5)
RING finger protein 11
Gene: RNF11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31985874
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 4374 Hs			1 154
+	Mm
		1208051 ITCH_MOUSE (3507-4372): 0: 685: 24.20		RNF11_MOUSE (1-154): 1.27e-42: 140: 99.35
+	Hs
		1294890 ITCH_HUMAN (3507-4372): 0: 672: 23.10		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Mm
		808380 NEDD4_MOUSE (3603-4372): 0: 639: 27.33		RNF11_MOUSE (1-154): 1.27e-42: 140: 99.35
+	Hs
		1240725 ITCH_HUMAN (3507-4372): 0: 672: 23.10		RN149_HUMAN (54-147): 1.09e-25: 102: 34.04
+	Hs
		1255979 ITCH_HUMAN (3507-4372): 0: 672: 23.10		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		125810 WWP2_HUMAN (3506-4372): 0: 624: 24.57		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1336128 SMUF1_HUMAN (3772-4371): 0: 620: 32.84		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1299666 NED4L_HUMAN (3542-4372): 0: 618: 27.53		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1327938 WWP1_HUMAN (3507-4372): 0: 613: 22.55		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1334883 SMUF2_HUMAN (3771-4371): 0: 611: 33.44		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		808333 NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		125596 WWP2_HUMAN (3506-4372): 0: 624: 24.57		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1255980 NED4L_HUMAN (3542-4372): 0: 618: 27.53		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1334874 SMUF2_HUMAN (3771-4371): 0: 611: 33.44		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29