HitPredict

Interactor 1: TMED4 (Q7Z7H5)
Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3)
Gene: TMED4

Interactor 2: GORS2 (Q9H8Y8)
Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59)
Gene: GORASP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005794 - Golgi apparatus GO:0007030 - Golgi organization
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 227 Hs			1 452
+	Rn
		1126543 TMED9_RAT (4-227): 4.88e-87: 258: 76.99		GORS2_RAT (1-451): 1.08e-104: 320: 88.79
+	Hs
		1313965 TMED9_HUMAN (8-227): 1.16e-91: 270: 77.93		GORS2_HUMAN (1-452): 3.63e-100: 308: 100.00
+	Rn
		1144353 TMEDA_RAT (1-227): 1e-69: 214: 32.61		GORS2_RAT (1-451): 1.08e-104: 320: 88.79
+	Rn
		88733 TMED7_RAT (24-225): 5.17e-68: 210: 24.75		GORS2_RAT (1-451): 1.08e-104: 320: 88.79
+	Rn
		192499 TMED9_RAT (4-227): 4.88e-87: 258: 76.99		GORS1_RAT (1-451): 8.63e-86: 271: 35.95
+	Hs
		1333961 TMED7_HUMAN (24-225): 2.11e-67: 208: 25.25		GORS2_HUMAN (1-452): 3.63e-100: 308: 100.00
+	Rn
		1144348 TMED2_RAT (28-227): 3.04e-62: 194: 23.50		GORS2_RAT (1-451): 1.08e-104: 320: 88.79
+	Hs
		833340 TMEDA_HUMAN (27-227): 8.94e-67: 206: 32.84		GORS2_HUMAN (1-452): 3.63e-100: 308: 100.00
+	Hs
		1071841 TMED2_HUMAN (28-227): 3.04e-62: 194: 23.50		GORS2_HUMAN (1-452): 3.63e-100: 308: 100.00
+	Hs
		1333964 TMED3_HUMAN (25-227): 3.26e-61: 192: 22.06		GORS2_HUMAN (1-452): 3.63e-100: 308: 100.00
+	Hs
		1309803 TMED7_HUMAN (24-225): 2.11e-67: 208: 25.25		GORS1_HUMAN (1-444): 3.85e-88: 277: 37.83
+	Hs
		1071819 TMED2_HUMAN (28-227): 3.04e-62: 194: 23.50		GORS1_HUMAN (1-444): 3.85e-88: 277: 37.83
+	Hs
		1309805 TMED3_HUMAN (25-227): 3.26e-61: 192: 22.06		GORS1_HUMAN (1-444): 3.85e-88: 277: 37.83
+	Rn
		192501 TMED2_RAT (28-227): 3.04e-62: 194: 23.50		GORS1_RAT (1-451): 8.63e-86: 271: 35.95
+	Sc
		698408 EMP24_YEAST (17-227): 2.69e-52: 169: 24.06		SEC31_YEAST (181-438): 8.19e-10: 63.4: 11.07
+	Sc
		758547 TMEDA_YEAST (14-227): 1.47e-51: 167: 25.91		SEC31_YEAST (181-438): 8.19e-10: 63.4: 11.07