HitPredict

Interactor 1: FBX2 (Q80UW2)
F-box only protein 2
Gene: Fbxo2

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	17215248, 17494702
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F-box-like~Skp1, FBA~Skp1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 297 Mm			1 163
+	Hs
		929104 FBX2_HUMAN (1-297): 7.16e-141: 400: 87.00		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		929075 FBX6_HUMAN (46-297): 1.3e-132: 379: 49.21		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		929059 FBX44_HUMAN (47-297): 4.11e-127: 364: 49.41		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		929028 FBX17_HUMAN (51-295): 1.28e-102: 302: 36.70		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		929000 FBX27_HUMAN (64-295): 6.24e-99: 293: 39.37		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Ce
		105469 Q17962_CAEEL (54-295): 3.29e-82: 254: 18.40		SKR1_CAEEL (4-162): 1.3e-80: 237: 70.81
+	Ce
		106001 Q17962_CAEEL (54-295): 3.29e-82: 254: 18.40		G5EDD8_CAEEL (4-162): 4.74e-67: 203: 60.25