HitPredict

Interactor 1: CBLC (Q80XL1)
E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)
Gene: CBLC

Interactor 2: SH2B2 (Q9JID9)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12842890
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 496 Mm			1 621
+	Mm
		610649 CBL_MOUSE (14-483): 0: 683: 45.42		SH2B2_MOUSE (1-621): 0: 540: 100.00
+	Hs
		548699 CBLB_HUMAN (4-468): 0: 680: 42.28		VAV_HUMAN (181-602): 1.84e-67: 237: 11.57
+	Mm
		82736 B9EKI5_MOUSE (4-468): 0: 683: 42.48		VAV2_MOUSE (181-599): 1.44e-59: 215: 12.58
+	Hs
		209046 CBLB_HUMAN (4-468): 0: 680: 42.28		NCK2_HUMAN (163-499): 3.49e-54: 191: 14.89
+	Mm
		403415 CBL_MOUSE (14-483): 0: 683: 45.42		SRC_MOUSE (283-513): 7.56e-50: 183: 14.74
+	Mm
		610633 CBL_MOUSE (14-483): 0: 683: 45.42		NCK1_MOUSE (163-499): 3.05e-50: 180: 14.45
+	Mm
		82738 B9EKI5_MOUSE (4-468): 0: 683: 42.48		NCK1_MOUSE (163-499): 3.05e-50: 180: 14.45
+	Mm
		223012 CBLB_MOUSE (4-468): 0: 684: 42.48		NCK2_MOUSE (163-499): 9.07e-49: 176: 14.61
+	Hs
		557678 CBLB_HUMAN (4-468): 0: 680: 42.28		NCK1_HUMAN (163-499): 6.22e-50: 179: 14.16
+	Mm
		610582 CBL_MOUSE (14-483): 0: 683: 45.42		SHC1_MOUSE (299-507): 4.64e-45: 170: 20.85
+	Hs
		522956 CBLB_HUMAN (4-468): 0: 680: 42.28		SRC_HUMAN (283-513): 3.5e-41: 159: 15.87
+	Mm
		610604 CBL_MOUSE (14-483): 0: 683: 45.42		PLCG1_MOUSE (393-616): 5.75e-38: 153: 15.18
+	Hs
		562643 CBLB_HUMAN (4-468): 0: 680: 42.28		PLCG2_HUMAN (393-616): 2.46e-34: 142: 14.29
+	Mm
		782847 CBLB_MOUSE (4-468): 0: 684: 42.48		CSK_MOUSE (403-489): 8.79e-30: 124: 29.89
+	Mm
		610555 CBL_MOUSE (14-483): 0: 683: 45.42		CSK_MOUSE (403-489): 8.79e-30: 124: 29.89
+	Mm
		815729 CBLB_MOUSE (4-468): 0: 684: 42.48		KSYK_MOUSE (409-515): 9.62e-16: 82.8: 22.02
+	Mm
		610566 CBL_MOUSE (14-483): 0: 683: 45.42		KSYK_MOUSE (409-515): 9.62e-16: 82.8: 22.02
+	Mm
		1112053 CBLB_MOUSE (4-468): 0: 684: 42.48		GRB2_MOUSE (403-491): 8.49e-16: 78.5: 26.97
+	Mm
		610598 CBL_MOUSE (14-483): 0: 683: 45.42		GRB2_MOUSE (403-491): 8.49e-16: 78.5: 26.97
+	Mm
		82735 B9EKI5_MOUSE (4-468): 0: 683: 42.48		GRB2_MOUSE (403-491): 8.49e-16: 78.5: 26.97