HitPredict

Interactor 1: MASP2 (O00187)
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
Gene: MASP2

Interactor 2: CO4A (P0C0L4)
Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain]
Gene: C4A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.882

The method score is based on:

Property Details
Experiments 36100602, 22949645, 22071314, 23785123
Identification Methods enzymatic study, x-ray crystallography, enzyme linked immunosorbent assay, solid phase assay
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains A2M~Sushi, A2M_BRD~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement, A2M_recep~Trypsin, MG2~Trypsin
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006958 - complement activation, classical pathway
GO:0070062 - extracellular exosome
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 686
Hs

1 1744
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024