HitPredict

Interactor 1: MASP2 (O00187)
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
Gene: MASP2

Interactor 2: MASP1 (P48740)
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
Gene: MASP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 10878362, 23785123
Identification Methods affinity chromatography technology, solid phase assay, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CUB~CUB, CUB~Sushi, CUB~EGF_CA, Sushi~Sushi, Sushi~Trypsin, Trypsin~Trypsin
Common GO terms GO:0001867 - complement activation, lectin pathway
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
and 2 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 686
Hs

1 699
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Last updated: 15 Jul 2024