HitPredict

Interactor 1: ARVC (O00192)
Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)
Gene: ARVCF

Interactor 2: CADH5 (P33151)
Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Gene: CDH5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~CADH_Y-type_LIR
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0007043 - cell-cell junction assembly GO:0045296 - cadherin binding GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 962 Hs			1 784
+	Hs
		239063 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH5_HUMAN (1-784): 0: 794: 100.00
+	Mm
		677630 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH5_MOUSE (1-783): 0: 750: 74.68
+	Mm
		702740 ARVC_MOUSE (1-962): 0: 879: 91.60		CAD15_MOUSE (31-777): 0: 614: 30.57
+	Hs
		119764 ARVC_HUMAN (1-962): 0: 869: 100.00		CAD15_HUMAN (15-776): 0: 613: 32.12
+	Mm
		454953 ARVC_MOUSE (1-962): 0: 879: 91.60		CADH1_MOUSE (25-780): 0: 582: 30.99
+	Hs
		119753 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH1_HUMAN (26-780): 0: 590: 31.71
+	Hs
		239165 CTND1_HUMAN (1-933): 0: 750: 46.14		CAD24_HUMAN (1-782): 0: 684: 35.90
+	Mm
		454947 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH1_MOUSE (25-780): 0: 582: 30.99
+	Hs
		239034 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH1_HUMAN (26-780): 0: 590: 31.71
+	Hs
		239052 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH3_HUMAN (32-780): 0: 574: 30.49
+	Hs
		119763 ARVC_HUMAN (1-962): 0: 869: 100.00		CAD12_HUMAN (1-469): 7.9e-89: 298: 23.46
+	Hs
		119762 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH8_HUMAN (1-469): 2.58e-86: 292: 22.75
+	Mm
		544706 ARVC_MOUSE (1-962): 0: 879: 91.60		CADH2_MOUSE (1-469): 3.89e-62: 227: 20.83
+	Hs
		119755 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH2_HUMAN (1-469): 4.36e-61: 224: 20.67
+	Hs
		522286 PKP3_HUMAN (19-852): 9.74e-160: 491: 26.20		CADH1_HUMAN (26-780): 0: 590: 31.71
+	Hs
		239096 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH8_HUMAN (1-469): 2.58e-86: 292: 22.75
+	Mm
		544697 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH2_MOUSE (1-469): 3.89e-62: 227: 20.83
+	Hs
		239097 CTND1_HUMAN (1-933): 0: 750: 46.14		CAD11_HUMAN (1-369): 2.44e-62: 225: 17.25
+	Hs
		239048 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH2_HUMAN (1-469): 4.36e-61: 224: 20.67
+	Hs
		996022 PKP3_HUMAN (19-852): 9.74e-160: 491: 26.20		DSC1_HUMAN (20-652): 2.45e-49: 189: 29.17