HitPredict

Interactor 1: RB27B (O00194)
Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG)
Gene: RAB27B

Interactor 2: RAE2 (P26374)
Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2)
Gene: CHML

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 218 Hs			1 656
+	Hs
		591451 RAB3A_HUMAN (2-218): 1.3e-91: 269: 39.63		RAE2_HUMAN (1-656): 0: 980: 100.00
+	Hs
		642723 RAB1A_HUMAN (1-217): 6.73e-85: 252: 35.62		RAE2_HUMAN (1-656): 0: 980: 100.00
+	Hs
		642743 RAB1B_HUMAN (3-217): 6.52e-84: 249: 36.28		RAE2_HUMAN (1-656): 0: 980: 100.00
+	Hs
		642722 RB11A_HUMAN (3-217): 1.17e-80: 241: 34.55		RAE2_HUMAN (1-656): 0: 980: 100.00
+	Hs
		591450 RAB3A_HUMAN (2-218): 1.3e-91: 269: 39.63		RAE1_HUMAN (1-652): 0: 946: 71.98
+	Hs
		119850 RB27B_HUMAN (1-218): 4.2e-87: 257: 100.00		RAE1_HUMAN (1-652): 0: 946: 71.98
+	Hs
		622577 RAB1A_HUMAN (1-217): 6.73e-85: 252: 35.62		RAE1_HUMAN (1-652): 0: 946: 71.98
+	Hs
		622619 RAB1B_HUMAN (3-217): 6.52e-84: 249: 36.28		RAE1_HUMAN (1-652): 0: 946: 71.98
+	Hs
		622576 RB11A_HUMAN (3-217): 1.17e-80: 241: 34.55		RAE1_HUMAN (1-652): 0: 946: 71.98
+	Mm
		838710 RAB3A_MOUSE (2-218): 5.15e-92: 270: 39.63		GDIA_MOUSE (167-599): 1.13e-141: 422: 20.49
+	Hs
		591453 RAB3A_HUMAN (2-218): 1.3e-91: 269: 39.63		GDIA_HUMAN (167-599): 2.93e-141: 421: 20.49
+	Hs
		591462 RAB3A_HUMAN (2-218): 1.3e-91: 269: 39.63		GDIB_HUMAN (221-606): 7.43e-140: 417: 21.52
+	Dm
		627447 RAB3_DROME (2-218): 3.01e-90: 266: 41.36		Q9VLB7_DROME (176-547): 7.18e-140: 417: 23.75
+	Mm
		838709 RAB1A_MOUSE (1-217): 6.73e-85: 252: 35.62		GDIA_MOUSE (167-599): 1.13e-141: 422: 20.49
+	Hs
		678344 RAB1A_HUMAN (1-217): 6.73e-85: 252: 35.62		GDIA_HUMAN (167-599): 2.93e-141: 421: 20.49
+	Hs
		678394 RAB1B_HUMAN (3-217): 6.52e-84: 249: 36.28		GDIA_HUMAN (167-599): 2.93e-141: 421: 20.49
+	Hs
		838625 RAB1A_HUMAN (1-217): 6.73e-85: 252: 35.62		GDIB_HUMAN (221-606): 7.43e-140: 417: 21.52
+	Dm
		185501 O18332_DROME (1-218): 7.96e-84: 249: 35.46		Q9VLB7_DROME (176-547): 7.18e-140: 417: 23.75
+	Hs
		838683 RAB1B_HUMAN (3-217): 6.52e-84: 249: 36.28		GDIB_HUMAN (221-606): 7.43e-140: 417: 21.52
+	At
		656917 RAE1C_ARATH (5-217): 3.73e-81: 242: 40.00		REP_ARATH (201-615): 1.59e-122: 377: 25.86