HitPredict

Interactor 1: ATG4D (Q86TL0)
Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 4) (Autophagin-4) (Autophagy-related protein 4 homolog D) (HsAPG4D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]
Gene: ATG4D

Interactor 2: GBRL1 (Q9H0R8)
Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Gene: GABARAPL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19549685
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ATG8~Peptidase_C54
Common GO terms	GO:0000045 - autophagosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 474 Hs			1 117
+	Hs
		891203 ATG4D_HUMAN (1-474): 0: 733: 100.00		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		306219 ATG4D_HUMAN (1-474): 0: 733: 100.00		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		1198602 ATG4D_HUMAN (1-474): 0: 733: 100.00		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		1288559 ATG4C_HUMAN (60-474): 0: 531: 46.04		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		306269 ATG4C_HUMAN (60-474): 0: 531: 46.04		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		1288558 ATG4C_HUMAN (60-474): 0: 531: 46.04		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		891370 ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1328075 ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		306368 ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Mm
		1206409 ATG4B_MOUSE (93-474): 1.51e-156: 451: 30.66		MLP3A_MOUSE (5-116): 1.09e-44: 142: 34.21
+	Ce
		999365 ATG42_CAEEL (54-460): 2.79e-142: 419: 31.83		LGG1_CAEEL (1-116): 3.74e-55: 169: 78.45
+	Hs
		1315816 ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66		MLP3C_HUMAN (5-116): 1.61e-44: 143: 39.47
+	Hs
		1330686 ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		891248 ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1326231 ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		61909 ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66		MP3B2_HUMAN (2-116): 6.71e-43: 138: 30.77
+	Hs
		1264549 ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		306253 ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		1264550 ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1264548 ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62