HitPredict

Interactor 1: RB27B (O00194)
Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG)
Gene: RAB27B

Interactor 2: SYTL4 (Q96C24)
Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
Gene: SYTL4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	28514442, 11956164, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0006887 - exocytosis GO:0045921 - positive regulation of exocytosis GO:0070382 - exocytic vesicle GO:0071985 - multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 218 Hs			1 671
+	Hs
		591484 RAB3A_HUMAN (2-218): 1.3e-91: 269: 39.63		SYTL4_HUMAN (1-671): 0: 587: 100.00
+	Hs
		320135 RAB3D_HUMAN (2-218): 3.78e-90: 265: 41.48		SYTL4_HUMAN (1-671): 0: 587: 100.00
+	Mm
		926098 RAB3A_MOUSE (2-218): 5.15e-92: 270: 39.63		SYTL4_MOUSE (1-671): 0: 564: 90.19
+	Mm
		1307925 RB27B_MOUSE (1-218): 7.13e-86: 254: 94.50		SYTL4_MOUSE (1-671): 0: 564: 90.19
+	Hs
		591482 RAB3A_HUMAN (2-218): 1.3e-91: 269: 39.63		SYTL5_HUMAN (2-669): 9.15e-161: 481: 38.17
+	Hs
		119864 RB27B_HUMAN (1-218): 4.2e-87: 257: 100.00		SYTL5_HUMAN (2-669): 9.15e-161: 481: 38.17
+	Hs
		914240 RB11A_HUMAN (3-217): 1.17e-80: 241: 34.55		SYTL5_HUMAN (2-669): 9.15e-161: 481: 38.17
+	Hs
		119859 RB27B_HUMAN (1-218): 4.2e-87: 257: 100.00		SYTL3_HUMAN (1-660): 8.26e-126: 387: 30.00
+	Hs
		119873 RB27B_HUMAN (1-218): 4.2e-87: 257: 100.00		SYTL2_HUMAN (123-664): 6.9e-94: 312: 33.15
+	Hs
		119861 RB27B_HUMAN (1-218): 4.2e-87: 257: 100.00		SYTL1_HUMAN (110-665): 1.09e-83: 276: 29.62
+	Hs
		1134943 RAB1B_HUMAN (3-217): 6.52e-84: 249: 36.28		SYT6_HUMAN (224-660): 2.2e-85: 279: 21.56
+	Mm
		812772 RAB3A_MOUSE (2-218): 5.15e-92: 270: 39.63		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Rn
		812780 RAB3A_RAT (2-218): 5.15e-92: 270: 39.63		RP3A_RAT (518-671): 1.13e-28: 123: 22.49
+	Hs
		591501 RAB3A_HUMAN (2-218): 1.3e-91: 269: 39.63		RP3A_HUMAN (518-671): 1.14e-28: 123: 23.08
+	Mm
		812771 RAB3C_MOUSE (2-218): 1.14e-89: 264: 39.91		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Hs
		119877 RB27B_HUMAN (1-218): 4.2e-87: 257: 100.00		RP3A_HUMAN (518-671): 1.14e-28: 123: 23.08
+	Mm
		812776 RB27B_MOUSE (1-218): 7.13e-86: 254: 94.50		RP3A_MOUSE (518-671): 6.38e-29: 124: 22.49
+	Mm
		926089 RAB3A_MOUSE (2-218): 5.15e-92: 270: 39.63		RIMS1_MOUSE (108-637): 1.93e-18: 92.3: 13.94
+	Mm
		919021 RAB3C_MOUSE (2-218): 1.14e-89: 264: 39.91		RIMS1_MOUSE (108-637): 1.93e-18: 92.3: 13.94
+	Hs
		129082 RAB1A_HUMAN (1-217): 6.73e-85: 252: 35.62		SYT5_HUMAN (347-458): 3.13e-19: 92.2: 31.25