HitPredict

Interactor 1: SYVN1 (Q86TM6)
E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1)
Gene: SYVN1

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 617 Hs			1 1024
+	Hs
		610524 CBL_HUMAN (160-604): 1.08e-48: 184: 14.43		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1237117 RN148_HUMAN (226-336): 1.57e-25: 109: 23.39		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		610507 CBL_HUMAN (160-604): 1.08e-48: 184: 14.43		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		610478 CBL_HUMAN (160-604): 1.08e-48: 184: 14.43		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Mm
		610561 CBL_MOUSE (160-612): 2.32e-49: 186: 13.97		NEDD4_MOUSE (652-1023): 1.58e-163: 505: 25.78
+	Ce
		1149482 Q6ABG8_CAEEL (160-437): 4.33e-38: 149: 13.85		WWP1_CAEEL (554-1024): 1.71e-172: 526: 21.95
+	Ce
		1090466 Q19019_CAEEL (160-457): 7.75e-35: 141: 13.91		WWP1_CAEEL (554-1024): 1.71e-172: 526: 21.95
+	Hs
		1240725 RN149_HUMAN (159-423): 6.7e-35: 138: 17.98		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		808111 CBLB_HUMAN (160-503): 1.21e-32: 136: 14.29		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		1294885 CBLC_HUMAN (162-413): 1.67e-31: 130: 14.18		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		125596 RN128_HUMAN (159-436): 1.26e-29: 123: 15.30		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		1255979 RN128_HUMAN (159-436): 1.26e-29: 123: 15.30		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		1255980 RN128_HUMAN (159-436): 1.26e-29: 123: 15.30		NED4L_HUMAN (652-1023): 2.49e-164: 510: 28.13
+	Hs
		1148113 RNF43_HUMAN (191-616): 6.1e-29: 124: 12.80		HECW1_HUMAN (532-1024): 4.53e-156: 504: 22.94