HitPredict

Interactor 1: HRK (O00198)
Activator of apoptosis harakiri (BH3-interacting domain-containing protein 3) (Neuronal death protein DP5)
Gene: HRK

Interactor 2: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.605

Property	Details
Experiments	15694340, 9130713
Identification Methods	unspecified method, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0006915 - apoptotic process GO:0016020 - membrane GO:0043065 - positive regulation of apoptotic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 91 Hs			1 239
+	Hs
		119881 HRK_HUMAN (1-91): 2.06e-42: 135: 100.00		B2CL1_HUMAN (11-239): 2.9e-77: 234: 42.68
+	Hs
		119884 HRK_HUMAN (1-91): 2.06e-42: 135: 100.00		B2CL2_HUMAN (50-239): 5.97e-51: 166: 40.31
+	Hs
		119883 HRK_HUMAN (1-91): 2.06e-42: 135: 100.00		B2LA1_HUMAN (84-235): 2.97e-44: 148: 23.42
+	Hs
		119882 HRK_HUMAN (1-91): 2.06e-42: 135: 100.00		MCL1_HUMAN (68-232): 6.24e-39: 139: 22.89