HitPredict

Interactor 1: HRK (O00198)
Activator of apoptosis harakiri (BH3-interacting domain-containing protein 3) (Neuronal death protein DP5)
Gene: HRK

Interactor 2: MCL1 (Q07820)
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
Gene: MCL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.49	0.60	0.545

Property	Details
Experiments	15694340, 15031724
Identification Methods	unspecified method, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0016020 - membrane GO:0043065 - positive regulation of apoptotic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 91 Hs			1 350
+	Hs
		119879 HRK_HUMAN (1-91): 2.06e-42: 135: 100.00		BCL2_HUMAN (204-347): 7.44e-53: 176: 25.00
+	Hs
		119881 HRK_HUMAN (1-91): 2.06e-42: 135: 100.00		B2CL1_HUMAN (190-346): 4.45e-50: 168: 24.10
+	Hs
		119884 HRK_HUMAN (1-91): 2.06e-42: 135: 100.00		B2CL2_HUMAN (200-346): 3.24e-43: 149: 21.88
+	Hs
		119883 HRK_HUMAN (1-91): 2.06e-42: 135: 100.00		B2LA1_HUMAN (187-323): 6.31e-37: 132: 22.54