HitPredict

Interactor 1: AP3B1 (O00203)
AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)
Gene: AP3B1

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005794 - Golgi apparatus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1094 Hs			1 465
+	Hs
		212576 AP1G1_HUMAN (16-830): 0: 579: 13.12		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227112 AP2B1_HUMAN (33-744): 0: 558: 25.14		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227287 AP1B1_HUMAN (33-725): 2.94e-176: 542: 25.56		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226166 AP2A1_HUMAN (42-648): 1.93e-154: 486: 14.02		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Zm
		111864 K7VAA4_MAIZE (8-862): 0: 583: 14.01		Q42415_MAIZE (1-153): 8.84e-50: 179: 20.13
+	Hs
		321678 AP2A1_HUMAN (42-648): 1.93e-154: 486: 14.02		ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67
+	At
		1091811 AP2A2_ARATH (21-1003): 0: 589: 12.62		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1092096 APBLA_ARATH (18-723): 0: 585: 22.57		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		302203 AP2A2_HUMAN (42-660): 3.11e-152: 479: 12.87		HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36
+	Zm
		111863 K7VAA4_MAIZE (8-862): 0: 583: 14.01		Q41754_MAIZE (1-76): 8.11e-30: 121: 31.58
+	At
		1091731 AP1G1_ARATH (13-862): 0: 563: 13.06		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475594 AP2B1_HUMAN (33-744): 0: 558: 25.14		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		286688 APBLC_ARATH (31-851): 2.48e-175: 538: 23.34		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1092397 APBLB_ARATH (31-851): 5.84e-173: 532: 22.99		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		321470 AP2A1_HUMAN (42-648): 1.93e-154: 486: 14.02		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091782 AP4E_ARATH (3-849): 8.4e-155: 486: 15.50		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		302094 AP2A2_HUMAN (42-660): 3.11e-152: 479: 12.87		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1092398 COPB1_ARATH (46-507): 1.93e-95: 327: 22.11		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17