Interactor 1: MTA70 (Q86U44)
N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70)
Gene: METTL3
Interactor 2: MET14 (Q9HCE5)
N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14)
Gene: METTL14
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.983 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 29489750, 29507755, 33961781, 36597993, 26496610, 30232453, 29506078, 33217317, 24316715, 27281194, 24394384, 27373337 |
| Identification Methods | affinity chromatography technology, comigration in non denaturing gel electrophoresis, x-ray crystallography, anti tag coimmunoprecipitation, x ray scattering, molecular sieving, pull down |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | MT-A70~MT-A70 |
| Common GO terms | GO:0000398 - mRNA splicing, via spliceosome GO:0001734 - mRNA m(6)A methyltransferase activity GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 8 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
