HitPredict

Interactor 1: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Interactor 2: LMO3 (Q8TAP4)
LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)
Gene: LMO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	16189514, 32296183, 33961781, unassigned1304, 20211142
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Hs			1 145
+	Hs
		1199129 LDB1_HUMAN (1-411): 0: 760: 100.00		ISL2_HUMAN (11-131): 2.07e-48: 160: 39.34
+	Hs
		1148473 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX8_HUMAN (12-132): 3.05e-46: 155: 39.67
+	Hs
		638328 LDB1_HUMAN (1-411): 0: 760: 100.00		RBTN2_HUMAN (13-133): 8.21e-46: 148: 60.33
+	Mm
		638608 LDB1_MOUSE (1-411): 0: 760: 99.76		RBTN2_MOUSE (13-133): 5.98e-46: 148: 60.33
+	Hs
		1199149 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX6_HUMAN (3-137): 8.85e-42: 143: 36.30
+	Hs
		899923 LDB1_HUMAN (1-411): 0: 760: 100.00		ISL1_HUMAN (4-132): 5.81e-39: 136: 36.15
+	Mm
		899939 LDB1_MOUSE (1-411): 0: 760: 99.76		ISL1_MOUSE (4-132): 5.81e-39: 136: 36.15
+	Hs
		903745 LDB1_HUMAN (1-411): 0: 760: 100.00		LMO4_HUMAN (11-142): 3.16e-41: 136: 50.76
+	Mm
		903798 LDB1_MOUSE (1-411): 0: 760: 99.76		LMO4_MOUSE (11-142): 3.16e-41: 136: 50.76
+	Hs
		638528 LDB1_HUMAN (1-411): 0: 760: 100.00		RBTN1_HUMAN (1-133): 5.2e-37: 125: 95.49
+	Hs
		1199128 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX4_HUMAN (72-144): 4.55e-12: 63.8: 19.18
+	Mm
		864804 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX4_MOUSE (72-144): 4.42e-12: 63.8: 19.18
+	Mm
		899945 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX5_MOUSE (4-67): 1.18e-11: 62.7: 26.15
+	Hs
		1199146 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX3_HUMAN (4-68): 2.41e-11: 61.9: 21.21
+	Hs
		822644 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX1_HUMAN (4-67): 3.28e-11: 61.5: 26.15
+	Hs
		238112 LDB1_HUMAN (1-411): 0: 760: 100.00		LMX1B_HUMAN (4-70): 5.05e-11: 60.8: 26.47
+	Mm
		291994 LDB1_MOUSE (1-411): 0: 760: 99.76		LMX1B_MOUSE (4-70): 5.16e-11: 60.8: 26.47
+	Mm
		839896 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX3_MOUSE (4-68): 6.86e-11: 60.4: 21.21
+	Hs
		1199143 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX9_HUMAN (77-143): 1.21e-10: 60: 25.00
+	Hs
		839771 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX2_HUMAN (12-78): 7.86e-10: 57.7: 23.53