HitPredict

Interactor 1: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Interactor 2: RNF12 (Q9NVW2)
E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)
Gene: RLIM

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	17437998, 20423330, 11882901
Identification Methods	affinity chromatography technology, experimental interaction detection
Interaction Type	physical association, ubiquitination reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 411 Hs			1 624
+	Hs
		1199151 LDB1_HUMAN (1-411): 0: 760: 100.00		RNF6_HUMAN (1-618): 1.59e-92: 301: 38.27
+	Hs
		210852 LDB2_HUMAN (44-411): 0: 620: 76.69		RNF12_HUMAN (1-624): 5.62e-119: 368: 100.00
+	Mm
		223261 LDB2_MOUSE (44-411): 0: 626: 76.42		RNF12_MOUSE (1-624): 1.04e-103: 328: 84.14
+	Hs
		1199140 LDB1_HUMAN (1-411): 0: 760: 100.00		RNF38_HUMAN (132-613): 1.34e-43: 165: 14.58