HitPredict

Interactor 1: LDB1 (Q86U70)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)
Gene: LDB1

Interactor 2: LHX6 (Q9UPM6)
LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1)
Gene: LHX6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	25416956, 26186194, 28514442, 32296183, 33961781, 35140242, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0030182 - neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Hs			1 363
+	Hs
		1148473 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX8_HUMAN (8-348): 4.5e-61: 201: 51.30
+	Hs
		238112 LDB1_HUMAN (1-411): 0: 760: 100.00		LMX1B_HUMAN (29-343): 5.52e-59: 197: 26.11
+	Mm
		291994 LDB1_MOUSE (1-411): 0: 760: 99.76		LMX1B_MOUSE (29-338): 9.66e-59: 196: 26.51
+	Mm
		899945 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX5_MOUSE (70-360): 1.34e-56: 191: 28.84
+	Hs
		899923 LDB1_HUMAN (1-411): 0: 760: 100.00		ISL1_HUMAN (60-360): 3.14e-56: 189: 26.94
+	Mm
		899939 LDB1_MOUSE (1-411): 0: 760: 99.76		ISL1_MOUSE (60-360): 3.14e-56: 189: 26.94
+	Hs
		1199143 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX9_HUMAN (8-344): 7.43e-55: 186: 24.03
+	Hs
		1199129 LDB1_HUMAN (1-411): 0: 760: 100.00		ISL2_HUMAN (61-343): 2.94e-53: 181: 28.05
+	Mm
		936884 LDB1_MOUSE (1-411): 0: 760: 99.76		ISL2_MOUSE (61-343): 3.8e-53: 181: 28.05
+	Hs
		822644 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX1_HUMAN (70-362): 1.71e-52: 180: 26.65
+	Mm
		925846 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX1_MOUSE (70-357): 1.46e-52: 180: 26.33
+	Hs
		839771 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX2_HUMAN (27-199): 1.4e-47: 167: 34.46
+	Mm
		936883 LDB1_MOUSE (1-411): 0: 760: 99.76		RBTN1_MOUSE (60-189): 3.54e-43: 148: 38.35
+	Hs
		903745 LDB1_HUMAN (1-411): 0: 760: 100.00		LMO4_HUMAN (43-181): 2.86e-24: 99.4: 39.44
+	Mm
		903798 LDB1_MOUSE (1-411): 0: 760: 99.76		LMO4_MOUSE (43-181): 2.86e-24: 99.4: 39.44
+	Hs
		1199128 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX4_HUMAN (3-124): 3.11e-19: 90: 11.81
+	Mm
		864804 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX4_MOUSE (3-124): 2.88e-19: 90: 11.81
+	Hs
		1199146 LDB1_HUMAN (1-411): 0: 760: 100.00		LHX3_HUMAN (4-124): 2.09e-18: 87.7: 14.52
+	Mm
		839896 LDB1_MOUSE (1-411): 0: 760: 99.76		LHX3_MOUSE (4-124): 2.27e-17: 84.6: 14.52
+	Hs
		638528 LDB1_HUMAN (1-411): 0: 760: 100.00		RBTN1_HUMAN (65-125): 1.45e-10: 61.1: 22.58