HitPredict

Interactor 1: AP3B1 (O00203)
AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)
Gene: AP3B1

Interactor 2: ARF6 (P62330)
ADP-ribosylation factor 6 (EC 3.6.5.2)
Gene: ARF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	11926829, 35844135
Identification Methods	pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Adaptin_N~Arf
Common GO terms	GO:0005794 - Golgi apparatus GO:0006886 - intracellular protein transport GO:0016020 - membrane GO:0016192 - vesicle-mediated transport GO:0034394 - protein localization to cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1094 Hs			1 175
+	Bt
		950590 AP3B1_BOVIN (1-1094): 0: 1002: 90.77		ARF1_BOVIN (2-175): 4.43e-69: 209: 68.39
+	Hs
		119949 AP3B1_HUMAN (1-1094): 0: 989: 100.00		ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39
+	Hs
		119950 AP3B1_HUMAN (1-1094): 0: 989: 100.00		ARF5_HUMAN (2-173): 4.69e-69: 209: 65.12
+	Hs
		119943 AP3B1_HUMAN (1-1094): 0: 989: 100.00		ARF3_HUMAN (2-175): 4.91e-65: 198: 69.54
+	Dm
		778390 Q9W4K1_DROME (2-1091): 0: 780: 46.58		ARF4_DROME (1-173): 3.53e-69: 209: 65.32
+	Dm
		897487 Q9W4K1_DROME (2-1091): 0: 780: 46.58		ARF1_DROME (2-175): 1.01e-64: 197: 70.12
+	Sc
		503110 AP3B_YEAST (19-736): 0: 594: 26.39		ARF1_YEAST (2-175): 2.05e-68: 207: 66.09
+	Hs
		212618 AP1G1_HUMAN (16-830): 0: 579: 13.12		ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39
+	Hs
		212615 AP1G1_HUMAN (16-830): 0: 579: 13.12		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		574776 AP4E1_HUMAN (6-1037): 1.84e-180: 559: 15.54		ARF4_HUMAN (1-173): 1.32e-70: 212: 64.74
+	Hs
		950578 AP4E1_HUMAN (6-1037): 1.84e-180: 559: 15.54		ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39
+	Hs
		950744 AP4E1_HUMAN (6-1037): 1.84e-180: 559: 15.54		ARF5_HUMAN (2-173): 4.69e-69: 209: 65.12
+	Hs
		913190 AP4E1_HUMAN (6-1037): 1.84e-180: 559: 15.54		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		897418 AP4E1_HUMAN (6-1037): 1.84e-180: 559: 15.54		ARF3_HUMAN (2-175): 4.91e-65: 198: 69.54
+	Hs
		912839 AP2B1_HUMAN (33-744): 0: 558: 25.14		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Hs
		950481 AP1B1_HUMAN (33-725): 2.94e-176: 542: 25.56		ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39
+	Dm
		778369 Q7KVR8_DROME (16-951): 2.45e-172: 533: 14.35		ARF4_DROME (1-173): 3.53e-69: 209: 65.32
+	Dm
		778364 Q24253_DROME (33-676): 1.42e-172: 532: 27.26		ARF4_DROME (1-173): 3.53e-69: 209: 65.32
+	Hs
		912875 AP1B1_HUMAN (33-725): 2.94e-176: 542: 25.56		ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00
+	Dm
		897446 Q7KVR8_DROME (16-951): 2.45e-172: 533: 14.35		ARF1_DROME (2-175): 1.01e-64: 197: 70.12