HitPredict

Interactor 1: MAGI2 (Q86UL8)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Atrophin-1-interacting protein A) (Membrane-associated guanylate kinase inverted 2) (MAGI-2)
Gene: MAGI2

Interactor 2: ARRD3 (Q96B67)
Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)
Gene: ARRDC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	23236378
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1455 Hs			1 414
+	Hs
		125633 WWP2_HUMAN (179-380): 1.6e-32: 139: 24.47		ARRD3_HUMAN (1-414): 2.2e-149: 431: 100.00
+	Hs
		1020203 PTN13_HUMAN (1003-1416): 5.21e-22: 106: 11.45		ARRD3_HUMAN (1-414): 2.2e-149: 431: 100.00
+	Hs
		125595 WWP2_HUMAN (179-380): 1.6e-32: 139: 24.47		ARRD2_HUMAN (1-411): 3.62e-128: 377: 53.16
+	Hs
		1256858 PARD3_HUMAN (389-522): 1.91e-13: 77.7: 29.45		ARRD3_HUMAN (1-414): 2.2e-149: 431: 100.00
+	Hs
		125586 WWP2_HUMAN (179-380): 1.6e-32: 139: 24.47		ARRD4_HUMAN (4-411): 1.8e-123: 365: 51.10
+	Hs
		125707 WWP2_HUMAN (179-380): 1.6e-32: 139: 24.47		TXNIP_HUMAN (1-399): 5.09e-112: 335: 40.75
+	Dm
		1249327 KIBRA_DROME (303-389): 9.87e-15: 82: 45.46		Q8SYU5_DROME (7-413): 4.59e-103: 315: 20.43
+	Dm
		115611 M9PFK2_DROME (278-381): 6.46e-11: 69.3: 32.14		Q8SYU5_DROME (7-413): 4.59e-103: 315: 20.43
+	Dm
		1249345 NEDD4_DROME (278-381): 6.14e-11: 69.3: 32.14		Q8SYU5_DROME (7-413): 4.59e-103: 315: 20.43
+	Dm
		115614 M9PFK2_DROME (278-381): 6.46e-11: 69.3: 32.14		Q9VI00_DROME (16-412): 5.73e-99: 303: 27.23
+	Dm
		1367624 NEDD4_DROME (278-381): 6.14e-11: 69.3: 32.14		Q9VI00_DROME (16-412): 5.73e-99: 303: 27.23
+	Hs
		125580 WWP2_HUMAN (179-380): 1.6e-32: 139: 24.47		ARRD1_HUMAN (3-412): 6.67e-68: 223: 21.43
+	Hs
		685901 DLG4_HUMAN (14-668): 3.51e-18: 92.9: 10.88		ARRB2_HUMAN (12-375): 9.8e-71: 230: 12.53
+	Dm
		115613 M9PFK2_DROME (278-381): 6.46e-11: 69.3: 32.14		Q9VHZ7_DROME (9-319): 2.49e-75: 245: 23.90
+	Dm
		1367606 NEDD4_DROME (278-381): 6.14e-11: 69.3: 32.14		Q9VHZ7_DROME (9-319): 2.49e-75: 245: 23.90
+	Hs
		1220067 KIBRA_HUMAN (303-390): 1.68e-15: 84.3: 45.56		ARRD1_HUMAN (3-412): 6.67e-68: 223: 21.43
+	Dm
		1365482 KIBRA_DROME (303-389): 9.87e-15: 82: 45.46		Q9VGU4_DROME (12-309): 4.75e-62: 210: 22.30
+	Ce
		101940 G1K0W3_CAEEL (892-1155): 8.25e-16: 85.3: 13.97		ARRB_CAEEL (12-382): 6.85e-59: 199: 13.69
+	Dm
		115612 M9PFK2_DROME (278-381): 6.46e-11: 69.3: 32.14		Q9VGU4_DROME (12-309): 4.75e-62: 210: 22.30
+	Dm
		1366431 NEDD4_DROME (278-381): 6.14e-11: 69.3: 32.14		Q9VGU4_DROME (12-309): 4.75e-62: 210: 22.30