HitPredict

Interactor 1: EST1A (Q86US8)
Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a)
Gene: SMG6

Interactor 2: SMG5 (Q9UPR3)
Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5)
Gene: SMG5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 20930030, 29395067
Identification Methods affinity chromatography technology, proximity labelling technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EST1~EST1_DNA_bind, EST1_DNA_bind~EST1_DNA_bind, PIN_4~PIN_4
Common GO terms GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0005634 - nucleus
GO:0005697 - telomerase holoenzyme complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 6 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 1419
Hs

1 1016
+ Hs
+ Hs
+ Hs
+ Zm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024