HitPredict

Interactor 1: ST2B1 (O00204)
Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1)
Gene: SULT2B1

Interactor 2: ST1A1 (P50225)
Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)
Gene: SULT1A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	25910212, 25416956, 33961781, 31515488
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid bait and prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Sulfotransfer_1~Sulfotransfer_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008146 - sulfotransferase activity GO:0050294 - steroid sulfotransferase activity GO:0050427 - 3'-phosphoadenosine 5'-phosphosulfate metabolic process and 1 others more... GO:0051923 - sulfation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 295
+	Hs
		120064 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST1A3_HUMAN (1-295): 5.82e-166: 464: 92.88
+	Hs
		120065 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST1A4_HUMAN (1-295): 5.82e-166: 464: 92.88
+	Hs
		120073 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST1A2_HUMAN (1-295): 3.26e-166: 464: 95.59
+	Hs
		120057 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST1C2_HUMAN (8-295): 1.72e-150: 424: 52.43
+	Hs
		120059 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST1B1_HUMAN (5-295): 1.44e-149: 422: 53.77
+	Hs
		120083 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST1C3_HUMAN (14-295): 4.12e-146: 413: 54.06
+	Hs
		120071 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST1E1_HUMAN (12-295): 4.06e-143: 406: 51.76
+	Hs
		120055 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST2B1_HUMAN (2-286): 8.16e-124: 360: 38.28
+	Hs
		838388 ST1A2_HUMAN (20-303): 8.65e-141: 403: 38.06		ST1A1_HUMAN (1-295): 2.45e-167: 467: 100.00
+	Hs
		483643 ST1A1_HUMAN (19-303): 9.44e-141: 403: 37.93		ST1A3_HUMAN (1-295): 5.82e-166: 464: 92.88
+	Hs
		483644 ST1A2_HUMAN (20-303): 8.65e-141: 403: 38.06		ST1A3_HUMAN (1-295): 5.82e-166: 464: 92.88
+	Hs
		483653 ST1A1_HUMAN (19-303): 9.44e-141: 403: 37.93		ST1A4_HUMAN (1-295): 5.82e-166: 464: 92.88
+	Hs
		483654 ST1A2_HUMAN (20-303): 8.65e-141: 403: 38.06		ST1A4_HUMAN (1-295): 5.82e-166: 464: 92.88
+	Hs
		120096 ST2B1_HUMAN (1-365): 0: 513: 100.00		ST4A1_HUMAN (14-291): 5.92e-109: 319: 33.45
+	Hs
		126295 ST1A1_HUMAN (19-303): 9.44e-141: 403: 37.93		ST1C2_HUMAN (8-295): 1.72e-150: 424: 52.43
+	Hs
		126296 ST1A2_HUMAN (20-303): 8.65e-141: 403: 38.06		ST1C2_HUMAN (8-295): 1.72e-150: 424: 52.43
+	Hs
		838406 ST1A2_HUMAN (20-303): 8.65e-141: 403: 38.06		ST4A1_HUMAN (14-291): 5.92e-109: 319: 33.45
+	Hs
		92570 ST1A1_HUMAN (19-303): 9.44e-141: 403: 37.93		E9PKR8_HUMAN (1-192): 6.05e-105: 305: 96.35