HitPredict

Interactor 1: SHLD2 (Q86V20)
Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2)
Gene: SHLD2

Interactor 2: SHLD1 (Q8IYI0)
Shieldin complex subunit 1 (RINN1-REV7-interacting novel NHEJ regulator 3) (Shield complex subunit 1)
Gene: SHLD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

The method score is based on:

Property	Details
Experiments	30022168, 30254264, 29656893
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0002208 - somatic diversification of immunoglobulins involved in immune response GO:0005694 - chromosome GO:0006281 - DNA repair GO:0035861 - site of double-strand break and 4 others more... GO:0043247 - telomere maintenance in response to DNA damage GO:0045830 - positive regulation of isotype switching GO:2000042 - negative regulation of double-strand break repair via homologous recombination GO:2001034 - positive regulation of double-strand break repair via nonhomologous end joining
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	835
Hs

1	205

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024