HitPredict

Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4

Interactor 2: SIGL5 (O15389)
Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)
Gene: SIGLEC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.681

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	LRR_4~V-set, Ig_3~LRR_8, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 839 Hs			1 551
+	Mm
		1265317 TLR4_MOUSE (1-823): 4.8e-132: 416: 67.23		SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77
+	Hs
		177592 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00
+	Hs
		177591 TLR5_HUMAN (12-816): 1.66e-88: 300: 19.74		SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00
+	Hs
		120171 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		SIG11_HUMAN (10-550): 1.07e-50: 186: 34.46
+	Mm
		1113884 TLR2_MOUSE (6-815): 4.15e-92: 309: 22.09		Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25
+	Hs
		120114 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		SIGL6_HUMAN (149-551): 8.41e-39: 149: 18.65
+	Hs
		120187 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		SIGL9_HUMAN (181-551): 5.6e-37: 144: 19.35
+	Hs
		120185 TLR4_HUMAN (1-839): 1.38e-145: 451: 100.00		SIGL7_HUMAN (181-551): 2.78e-34: 137: 20.60
+	Mm
		1162020 TLR4_MOUSE (1-823): 4.8e-132: 416: 67.23		Q6PJ50_MOUSE (192-551): 6.36e-45: 167: 19.59
+	Mm
		1265201 TLR4_MOUSE (1-823): 4.8e-132: 416: 67.23		SIG12_MOUSE (192-551): 6.63e-45: 166: 19.59
+	Mm
		1265318 TLR2_MOUSE (6-815): 4.15e-92: 309: 22.09		SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77
+	Hs
		237434 TLR5_HUMAN (12-816): 1.66e-88: 300: 19.74		SIG11_HUMAN (10-550): 1.07e-50: 186: 34.46
+	Mm
		722910 TLR2_MOUSE (6-815): 4.15e-92: 309: 22.09		CD22_MOUSE (30-547): 9.12e-47: 177: 17.09
+	Mm
		1162021 TLR2_MOUSE (6-815): 4.15e-92: 309: 22.09		Q6PJ50_MOUSE (192-551): 6.36e-45: 167: 19.59
+	Hs
		211412 TLR5_HUMAN (12-816): 1.66e-88: 300: 19.74		SIGL6_HUMAN (149-551): 8.41e-39: 149: 18.65
+	Hs
		237523 TLR2_HUMAN (19-815): 1.12e-90: 305: 22.15		SIGL9_HUMAN (181-551): 5.6e-37: 144: 19.35
+	Hs
		237440 TLR5_HUMAN (12-816): 1.66e-88: 300: 19.74		SIGL7_HUMAN (181-551): 2.78e-34: 137: 20.60
+	Hs
		237424 TLR5_HUMAN (12-816): 1.66e-88: 300: 19.74		CD33_HUMAN (251-549): 3.29e-28: 117: 23.74
+	Hs
		237425 TLR5_HUMAN (12-816): 1.66e-88: 300: 19.74		CD22_HUMAN (190-539): 2.31e-15: 81.5: 13.92
+	Mm
		1144432 TLR2_MOUSE (6-815): 4.15e-92: 309: 22.09		CD33_MOUSE (251-528): 3.45e-11: 67.3: 16.31