HitPredict - High confidence protein-protein interactions

Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4

Interactor 2: RIPK2 (O43353)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15691841
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_4~PK_Tyr_Ser-Thr, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005102 - signaling receptor binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0007254 - JNK cascade and 24 others more... GO:0031663 - lipopolysaccharide-mediated signaling pathway GO:0032722 - positive regulation of chemokine production GO:0032727 - positive regulation of interferon-alpha production GO:0032728 - positive regulation of interferon-beta production GO:0032729 - positive regulation of type II interferon production GO:0032731 - positive regulation of interleukin-1 beta production GO:0032735 - positive regulation of interleukin-12 production GO:0032755 - positive regulation of interleukin-6 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0032874 - positive regulation of stress-activated MAPK cascade GO:0034142 - toll-like receptor 4 signaling pathway GO:0042742 - defense response to bacterium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046330 - positive regulation of JNK cascade GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0051403 - stress-activated MAPK cascade GO:0060907 - positive regulation of macrophage cytokine production GO:0070371 - ERK1 and ERK2 cascade GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0070427 - nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070431 - nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0071223 - cellular response to lipoteichoic acid
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1	839
Hs

1	540

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Last updated: 15 Jul 2024