HitPredict

Interactor 1: THOC4 (Q86V81)
THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF)
Gene: ALYREF

Interactor 2: THOC3 (Q96J01)
THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)
Gene: THOC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	15998806, 17190602, 23222130
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000346 - transcription export complex GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0006406 - mRNA export from nucleus and 2 others more... GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 257 Hs			1 351
+	Hs
		903346 THOC4_HUMAN (1-257): 3.25e-47: 159: 100.00		WDR5_HUMAN (4-251): 1.76e-70: 224: 18.75
+	Hs
		903196 PABP4_HUMAN (97-252): 3.94e-21: 94: 19.50		WDR5_HUMAN (4-251): 1.76e-70: 224: 18.75
+	Hs
		516438 PABP1_HUMAN (97-252): 2.4e-20: 91.7: 18.24		WDR5_HUMAN (4-251): 1.76e-70: 224: 18.75
+	Hs
		1288289 PDIP3_HUMAN (58-192): 2.97e-15: 76.5: 30.15		SNR40_HUMAN (7-250): 1.12e-59: 197: 13.33
+	Hs
		197049 THOC4_HUMAN (1-257): 3.25e-47: 159: 100.00		PRP4_HUMAN (210-349): 1.27e-26: 111: 16.78
+	Hs
		1201119 THOC4_HUMAN (1-257): 3.25e-47: 159: 100.00		FBXW7_HUMAN (251-351): 8.37e-17: 83.5: 15.53
+	Hs
		1281368 PDIP3_HUMAN (58-192): 2.97e-15: 76.5: 30.15		FBXW7_HUMAN (251-351): 8.37e-17: 83.5: 15.53