HitPredict

Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4

Interactor 2: MBL2 (P11226)
Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin)
Gene: MBL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 1.00 0.819

The method score is based on:

Property Details
Experiments 19840833, 21383675
Identification Methods solid phase assay, anti tag coimmunoprecipitation, far western blotting, enzyme linked immunosorbent assay
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_8~Lectin_C
Common GO terms GO:0005102 - signaling receptor binding
GO:0009897 - external side of plasma membrane
GO:0009986 - cell surface
GO:0042742 - defense response to bacterium
GO:0045087 - innate immune response
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 839
Hs

1 248
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024