HitPredict

Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4

Interactor 2: TCAM1 (Q8IUC6)
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
Gene: TICAM1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 0.60 0.683

The method score is based on:

Property Details
Experiments 25736436, 31511519, 19656901, 14519765
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002224 - toll-like receptor signaling pathway
GO:0005769 - early endosome
GO:0006809 - nitric oxide biosynthetic process
GO:0006954 - inflammatory response
GO:0010008 - endosome membrane
and 16 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 839
Hs

1 712
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
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Last updated: 15 Jul 2024