HitPredict

Interactor 1: ZCH18 (Q86VM9)
Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)
Gene: ZC3H18

Interactor 2: PPIE (Q9UNP9)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Gene: PPIE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 29298432, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0016607 - nuclear speck
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 953 Hs			1 301
+	Hs
		203537 ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00		PPIH_HUMAN (131-300): 1.25e-91: 271: 55.11
+	Hs
		614372 ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00		PPIB_HUMAN (143-300): 5.03e-63: 199: 58.49
+	Hs
		923727 ZCH18_HUMAN (1-953): 3.56e-83: 290: 100.00		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46
+	Hs
		1246388 THOC2_HUMAN (248-635): 6.8e-20: 98.2: 14.15		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		1357564 SRRM2_HUMAN (7-950): 3.04e-18: 92.9: 11.64		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		1222876 SRRM1_HUMAN (39-841): 2.51e-14: 79.8: 12.14		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		923745 TITIN_HUMAN (139-952): 5.65e-14: 79: 9.54		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46
+	Hs
		673677 PRB3_HUMAN (741-951): 2.04e-09: 62.5: 8.06		PPIF_HUMAN (143-300): 1.34e-67: 211: 68.35
+	Hs
		923644 ANK2_HUMAN (498-952): 3.04e-11: 70.1: 14.63		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46
+	Hs
		614354 NIPBL_HUMAN (485-927): 6.3e-11: 68.9: 15.90		PPIB_HUMAN (143-300): 5.03e-63: 199: 58.49
+	Hs
		152624 KMT2D_HUMAN (379-947): 6.05e-11: 69: 11.30		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46