HitPredict

Interactor 1: TAXB1 (Q86VP1)
Tax1-binding protein 1 (TRAF6-binding protein)
Gene: TAX1BP1

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	19609363, 33545068
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome GO:0005829 - cytosol GO:0006914 - autophagy GO:0030674 - protein-macromolecule adaptor activity GO:0045087 - innate immune response and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 789 Hs			1 577
+	Hs
		1201960 TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		1061159 TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Hs
		1201957 TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77
+	Hs
		1025499 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Rn
		222472 MRCKA_RAT (76-763): 1.39e-52: 200: 12.52		MRCKA_RAT (87-531): 8.04e-29: 124: 15.29
+	Hs
		1025619 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Rn
		222476 MRCKA_RAT (76-763): 1.39e-52: 200: 12.52		MRCKB_RAT (39-551): 1.19e-09: 63.5: 12.19
+	Hs
		1137917 MRCKA_HUMAN (76-763): 9.09e-53: 201: 12.38		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77
+	Hs
		551687 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		1025488 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Hs
		725151 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		148801 CTRO_HUMAN (96-665): 2.04e-20: 99.2: 11.44		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		1025566 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		528370 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		MYH6_HUMAN (226-544): 5.47e-12: 71: 15.05
+	Hs
		724805 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		148359 CTRO_HUMAN (96-665): 2.04e-20: 99.2: 11.44		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		148126 CTRO_HUMAN (96-665): 2.04e-20: 99.2: 11.44		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		148461 CTRO_HUMAN (96-665): 2.04e-20: 99.2: 11.44		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		148466 CTRO_HUMAN (96-665): 2.04e-20: 99.2: 11.44		MYH11_HUMAN (263-576): 6.07e-11: 67.9: 15.36
+	Hs
		148460 CTRO_HUMAN (96-665): 2.04e-20: 99.2: 11.44		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08