HitPredict

Interactor 1: TAXB1 (Q86VP1)
Tax1-binding protein 1 (TRAF6-binding protein)
Gene: TAX1BP1

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	28877469, 31723608, 21885437
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045087 - innate immune response
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 789 Hs			1 729
+	Hs
		1050233 TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		158500 TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		1025586 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		167576 TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		1201957 TAXB1_HUMAN (1-789): 5.15e-85: 288: 100.00		MRCKB_HUMAN (6-700): 1.77e-108: 364: 16.10
+	Mm
		1112810 TAXB1_MOUSE (1-789): 9.67e-73: 255: 82.23		IKKA_MOUSE (9-637): 1.7e-120: 379: 20.94
+	Hs
		1025378 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		158459 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		1137871 MRCKA_HUMAN (76-763): 9.09e-53: 201: 12.38		MRCKA_HUMAN (6-698): 6.44e-109: 365: 17.31
+	Hs
		1137917 MRCKA_HUMAN (76-763): 9.09e-53: 201: 12.38		MRCKB_HUMAN (6-700): 1.77e-108: 364: 16.10
+	Rn
		222472 MRCKA_RAT (76-763): 1.39e-52: 200: 12.52		MRCKA_RAT (6-698): 5.51e-107: 360: 17.45
+	Rn
		222476 MRCKA_RAT (76-763): 1.39e-52: 200: 12.52		MRCKB_RAT (6-700): 1.94e-103: 349: 15.53
+	Hs
		158414 MYH10_HUMAN (290-756): 5.81e-16: 84.7: 10.02		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		167488 MYH11_HUMAN (315-745): 1.27e-16: 87: 10.96		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		167487 MYH10_HUMAN (290-756): 5.81e-16: 84.7: 10.02		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		522542 MYH1_HUMAN (181-778): 1.83e-23: 109: 9.33		CDK3_HUMAN (6-309): 7.85e-116: 352: 20.20
+	Hs
		728513 MYH11_HUMAN (315-745): 1.27e-16: 87: 10.96		SIK2_HUMAN (9-719): 1.2e-110: 359: 15.54
+	Hs
		625177 MYH10_HUMAN (290-756): 5.81e-16: 84.7: 10.02		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		262262 CACO2_HUMAN (7-339): 2.16e-36: 144: 27.00		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10